The CVS Pharmacy at the corner of Brookline Boulevard and Pioneer Avenues opened it's doors in 2000. It was the first major change to the Brookline Boulevard business district since Mazza Pavilion was built back in 1982.

  
Demolition of the Boulevard buildings and Berkshire homes, in 1999, made room for the new complex.

In 1999, during construction of the new pharmacy, several buildings were torn down to clear the site. Three buildings along the boulevard were demolished, Nolan's Hardware, the duplex that housed Brookline Pharmacy, and the corner building that housed Giorgio's Pizza (previously Myer's Service Station). Three homes on the corner of Berkshire Avenue were also razed, and the alleyway behind them diverted to exit onto Berkshire Avenue.

The intersection of Brookline Boulevard and Pioneer Avenue, in early 1999, prior to the start of construction.