Built in 1983, One Mellon Place is the headquarters of Mellon Bank. The 54 story skyscraper is the second tallest building in the City of Pittsburgh. It stands next to the US Steel Building on Grant Street, and dwarfs the Allegheny County Courthouse on its other side. Ironically, at one time the courthouse was the tallest building in the city.

The city subway system, or "T", has a stop at Steel Plaza, located underneath the building with tunnels connecting it to both Mellon Center and USX Tower. One Mellon Center is the heart of the four building Mellon Bank Headquarters Complex here in Pittsburgh. Included is Three Mellon Center, a 41 story skyscraper adjacent to Mellon Square.